A Data Driven Applied Aging Research Project

Hacking Biology (HB) is an applied research project that aim to bring a Do It Yourself (DIY) experimental protocol to address biological hallmark of aging.

While we are neither developing a Trial Protocol, neither doing hot science, the protocol develop arounds scientific finding (being earlystage or established, having already had human testing or only on other mammals) by identifying:

• Which biological effect do we want to trigger
• How the specific biological effect is achieved
• How the outcome of the Biomarker can be measured/compared

Inspired by the approach of Bryan Jonhson with a deep focus on measurements, HB target many specific biological KPIs (defined as Biomarkers) with the simplified therapeutic goal to bring them to a younger than chronological age equivalence.

The more the biological KPIs we can restore to a younger-than-chronological-age, then the healthier and slowed down aging we will face.

Many Doctors and Biologists would badly react upon the above assumptions, especially given the high complex interaction of a wide supplementing and therapeutical strategy, that may result in unexpected medical outcomes.

But this is an hacking project, means we need to get really applied, iteratively operating over the data and the corresponding scienfic indications and evidences to drive our goal to change several of our body numbers.

Tweaking with the low-level code of our biology is HB project goal, in a faster than medicine and cheaper than scientific trial way, doing it in following a logical, measurable and DIY-doable way.

HB’s founder and first guinea pig is Fabio Pietrosanti (naif), hacker, innovator, empreneur and open knowledge passionate, taking the effort and risks (yes, there are risks!) of applying protocol on himself during the development.

The project is made of few major components:

• Documenting research on the main aging targets
  • Key area of our aging targets with established scientific references
  • Exploration area, TODOs to be researched for use in the protocol
• Applied measurements (how to measure and what, the data!)
  • KPIs with reference targets by chronological age and baseline
  • How to collect the data (e.g. The blood panel to be given to your analisys laboratory)
  • Safety KPIs to keeps under control unexpected behaviours
• Applied therapeutic activities
  • Supplementing (NMN, Vitami B12, Quercetin, etc)
  • Pharmacological threatments (e.g. Methformin, Urolithin, etc)
  • Nutrition requirements (e.g. Calories restriction, Fasting 16/8, etc)
  • Lifestyle requirements (e.g. High intensity interval training, Sleeping, etc)
  • Specific therapeutic practices (e.g. Plasmapheresis, HBOT protocol, etc )
• Software to be built to manage multiple
  • Measurements
  • Therapeutics scheduling
  • Therapeutic sourcing and coordination
• Procurement and Sourcing
  • Selection and Database of Supplement suppliers
  • Technical requirements for measurement laboratories (e.g. Blood panel, DNA methylase, etc)
  • Technical requirements for therapeutic activities (e.g. Plasmapheresis)
• Hands-on practical experience in setting up everything

Project Presentation Slides

Work in progress (unstructured) “Protocol Planning” Spreadsheet.