Increasing oxygen while sleeping?

From the paper Hyperoxia enhances slow-wave forebrain states in urethane-anesthetized and naturally sleeping rats i’ve learned that increasing oxygen while sleeping seems to be improving sleep, clearing out metabolites from te brain and all in all increase the slow-wave status that consolidate memories, muscle crow and protein reforming.

The summary paper of the paper is Resting easy: Oxygen promotes deep, restorative sleep, study shows .

So i come up exploring the world of people having problem sleeping, and there’s a wonderworld of threatment with oxygen sleeping machine that could be used in the context of biohacking.

I’m now just exploring this area dumping in this post the search, there’s a bunch of companies such as sleeplay providing a lot of canula, tubex, oxygen generator machines, masks for people with sleep problems.

My first concern come up to: Do i want to sleep with a mask? Is that confortable? It would be like this:

So i found out a possible solutions with a mask-free injector of oxygen by this company oxyllowsystem that we can just put on the pillows like this:

It could also be possible to uses so call “altitude tent” that climbers uses to do the opposite, reduce the oxygen to create a mountain/altitude condition hypoxia (less oxigen) state while sleeping, such as those hypoxico company sell, but doing it with could means increasing risks of fire, and it could prove to be unpleasant to burn into the bed because a little electricity spark comes from the light on the side-bed-room, so maybe not worth it for a first testing:

Then we have to generate oxygen, and on this other company i found a nice explaination of difference between Oxygen Concentrator vs. CPAP machines that’s worth reading to come up with which is the right oxygen generator to uses:

A CPAP Machine it’s a device like this, relatively easy to stay on the side of the bed:

Oxygen Concentrator are device like this:

Still have to dig enough to understand, for such an experiment, what’s the best to buy.

Furthermore we would need to monitor how it does change our sleep.

For this we have to do two things:

A) Monitor sleep results: i’m already using a Garmin for sleep monitoring, activating a featured called “Advanced Sleep Tracking” . What we should expect is to have a reduced REM sleep but increase deep sleep time, according to the research paper.

B) Measure the oxygen in our blood with an oximeter. You can also buy a Garmin watch that does include SPO2 measurement, with a parameter that can be activated to measure oxygen saturation during sleep. Otherwise I found a professional sleeping monitoring toolkit but it could be valuable any kind of “night oximeter” that you can find on Amazon where the oximeter measuring oxygen saturation is stick to the finger in a confortable way such as:

Once i implement it, i will post the results.

Always remember, what we are looking is not to just increment Oxygen (that over a long time maybe toxic) but to create alternation of Oxygen higher level (hyperoxia), then dropping to normal level (normoxia), so that you hack your biology into thinking it went in low oxygen condition (hypoxia) leading to HIF-1 activation.

This is called The Hyperoxic-Hypoxic Paradox .

It’s then very relevant to program the Oxygen Concentrator to modulate the flow in an alternating way, for instance the

If in the meantime anyone want to try it out and share their experience, it would be lovely.

Posted a thread on Rapamycin news forum for followup.