My Blog on Hacking Biology

Pills Management

Thu, 14 Aug 2025 10:52:11 +0200

Pills management when you starts having a lot of pills is a pain, especially if you are:

A) Lazy

B) Busy

C) Doing it yourself (not like Bryan johnson paying an entire team)

Nutritional epigenetic

Sun, 16 Mar 2025 09:01:18 +0100

Today i come up with a lovely paper focusing specifically on improving DNA methylation “Potential reversal of biological age in women following an 8-week methylation-supportive diet and lifestyle program: a case series ” .

Increasing oxygen while sleeping?

Mon, 13 Jan 2025 07:31:10 +0100

From the paper Hyperoxia enhances slow-wave forebrain states in urethane-anesthetized and naturally sleeping rats i’ve learned that increasing oxygen while sleeping seems to be improving sleep, clearing out metabolites from te brain and all in all increase the slow-wave status that consolidate memories, muscle crow and protein reforming.

Many protocols for many pills

Wed, 01 Jan 2025 11:32:46 +0100

In the longevity ecosystem there’s way more protocols defined that could be taken inspiration, other than just Bryan Johnson and here’s my review in addressing my own development.

Danielle Wis reached the #1 spot on Rejuvination Leaderbord at 34yo with own protocol with a 5 of pills all from Renue by Science and focus on 11 biomarkers. He’s specifically looking at reducing telmere attrition and epigenetic dysfunction.

Measurements of biological age

Sun, 15 Dec 2024 21:47:22 +0100

The measurement of biological age can be done with many different way, this article provides the set of data we are going to uses in hackinbgiology:

GlycanAge : Cell aging affects glycosylation of immunoglobulin G (IgG) aging

Glucose and Rapamycin for Anti-Aging

Sat, 20 Jul 2024 13:35:25 +0200

It’s pretty clear that aging slowdown is directly related to the reduction of glucose in our blood and that Type-II diabetics drugs, almost all, bring in mammal experimentation a lifespan increase (Metformin, GLP-1 inhibitors such as Semaglutide/Liraglutide and Acarbose)

HBOT Protocol for aging

Sat, 20 Jul 2024 13:05:42 +0200

Hyperbatic Therapy with alternating hyperoxic oxygen administration has been proven to provides important benefits:

Telemere increase
Immunosenescence decrease
Blood Cells senescen

Famous researcher Shai Efrati , made up Aviv Clinic where i went visiting in Dubai that provides the HBOT threatment with intermittent hyperoxic oxigen protocol, with a lot of measurements to evaluate the effective of telemere increase and extra-vascularization in the brain and other tissues via MRI.

Project Update July 2024

Fri, 19 Jul 2024 15:22:40 +0200

During the 2023 the study has progressed and the 2024 has been the startup of basic experimentation with:

practical understanding on taking a lot of pills and measuring it (doing it in agile way, before going structural)

Software Review

Sun, 07 Jan 2024 17:23:58 +0100

This page aim to collect an unstructured, later to become structured, review and list of software and software libraries that can be used to:

Manage collection of exams results (Simple and elaborated Biomarkers)
Manage the ongoing tracking of multiple sampling over time
Collect therapeutics used in a research and/or DIY protocol

The mapping is done by analyzing both proprietary and free (open source) software, including SAAS (software as a service) and ones to be installed.

A Data Driven Applied Aging Research Project

Sun, 09 Jul 2023 18:59:26 +0200

Hacking Biology (HB) is an applied research project that aim to bring a Do It Yourself (DIY) experimental protocol to address biological hallmark of aging.

While we are neither developing a Trial Protocol, neither doing hot science, the protocol develop arounds scientific finding (being earlystage or established, having already had human testing or only on other mammals) by identifying: