Hacking Biology

Glucose and Rapamycin for Anti-Aging

It’s pretty clear that aging slowdown is directly related to the reduction of glucose in our blood and that Type-II diabetics drugs, almost all, bring in mammal experimentation a lifespan increase (Metformin, GLP-1 inhibitors such as Semaglutide/Liraglutide and Acarbose)

It’s pretty clear that senolytics effects of AMPK-metabolism, is what drive cleanup of senescent cells.

It has precisely identified the relationship between AMPK and Glucose levels:

“There are many biology observation of relationship between AMPK and Glucose levels, in bi-directional influence, but not a specific anti-aging protocol outside the fact that all diabetes type-II treatments increase lifespan. On the AMPK-Glucose relationship you can see AMP-activated protein kinase signaling in metabolic regulation”

Low level of glucose in blood givens the body understanding of being in a starvation mood, leading to AMPK release and increase of autophagic process.

Furthermore the leading drugs for longevity increase, Rapamycin, take care of inhibiting mTORC1, always associated with lifespan increase:

Low level of glucose, lead to inhibition of mTORC1:

“when glucose levels are low, mTORC1 is inhibited, in turn leading to the repression of numerous anabolic processes, sparing ATP and antioxidant”

Who takes Rapamcyin as a drug for the purpose of lifespan increase, experience an increase in insuline resistance, basically a “Rapamycin diabets” that can be really damaging. Sirolimus lead to Pancreas’s B-cells dysfunction and death, leading to diabets.

The good news is that glucagon-like peptide-1 receptor (GLP-1R) receptor antagonist, such as the well knows Semaglutide and Liraglutide T2D and weight-losing drugs, reduce such an effect.

By this assumptions, any Rapamycin mTORC1 inhibition longevity therapy should first starts lowing Glucose with existing longevity-increase T2D drugs (that already inhibits mTORC1) such as GLP-1R antagonist, Metformin and Acarbose and only once the glucose-level has been seriously lowered (my target is “slighly above hypoglicemic-level), then introduce Rapamycin.

Discussion on Rapamycin News forum for updates.

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One response to “Glucose and Rapamycin for Anti-Aging”

  1. Treon S Verdery Avatar
    Treon S Verdery

    “2 week rapamycin treatment in mice has detrimental metabolic effects
    •
    6 week rapamycin treatment leads to a metabolic transition
    •
    20 week rapamycin treatment improves metabolic profiles and insulin sensitivity
    •
    Both mTORC1 and mTORC2 are involved in mediating the effects of rapamycin”
    https://www.cell.com/cell-metabolism/fulltext/S1550-4131(13)00056-9

    That could make your thoughtful quandry less of a quandry, if you monitor Hba1c at 18, 28, 40 weeks.

    I am sure you are aware of this, but for others that read your post, it is possible to measure many of your body’s attributes with screening panels from lifeextension.com. So if people do not know their HBa1C, or would like to monitor it that is one way to do it. Do you know the two published studies with 100% heightened rodent longevity, and the two different published studies with 60% heightened rodent longevity, and their mouse dose of rapamycin? what is the equivalent human dose, I got a very large number 70-149mg, but I would really appreciate seeing your separate computation.

    Thanks,
    treonsverdery@gmail.com

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