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Pills management when you starts having a lot of pills is a pain, especially if you are: A) Lazy B) Busy C) Doing it yourself (not like Bryan johnson paying an entire team) In such an non ideal-condition i feel myself very in-line with Dave Pascoe, and from that perspective i do plan to follow…

Today i come up with a lovely paper focusing specifically on improving DNA methylation “Potential reversal of biological age in women following an 8-week methylation-supportive diet and lifestyle program: a case series” . It comes up an interesting concept, epinutrition (or nutritional epigenetic), that’s the specific set of food, compounds (and i’d add drugs) that…

From the paper Hyperoxia enhances slow-wave forebrain states in urethane-anesthetized and naturally sleeping rats i’ve learned that increasing oxygen while sleeping seems to be improving sleep, clearing out metabolites from te brain and all in all increase the slow-wave status that consolidate memories, muscle crow and protein reforming. The summary paper of the paper is…

In the longevity ecosystem there’s way more protocols defined that could be taken inspiration, other than just Bryan Johnson and here’s my review in addressing my own development. Danielle Wis reached the #1 spot on Rejuvination Leaderbord at 34yo with own protocol with a 5 of pills all from Renue by Science and focus on…

The measurement of biological age can be done with many different way, this article provides the set of data we are going to uses in hackinbgiology: GlycanAge: Cell aging affects glycosylation of immunoglobulin G (IgG) aging TruDiagnostic: DNA Methylation, changes in epigenetic patterns, can be measured with multiple “biological clock” algorithm: Moc Dexa Total Body:…

It’s pretty clear that aging slowdown is directly related to the reduction of glucose in our blood and that Type-II diabetics drugs, almost all, bring in mammal experimentation a lifespan increase (Metformin, GLP-1 inhibitors such as Semaglutide/Liraglutide and Acarbose) It’s pretty clear that senolytics effects of AMPK-metabolism, is what drive cleanup of senescent cells. It…

Hyperbatic Therapy with alternating hyperoxic oxygen administration has been proven to provides important benefits: Famous researcher Shai Efrati, made up Aviv Clinic where i went visiting in Dubai that provides the HBOT threatment with intermittent hyperoxic oxigen protocol, with a lot of measurements to evaluate the effective of telemere increase and extra-vascularization in the brain…

During the 2023 the study has progressed and the 2024 has been the startup of basic experimentation with: – practical understanding on taking a lot of pills and measuring it (doing it in agile way, before going structural) – making a bunch of exams and refine the exams and data needed to collect – understanding…

This page aim to collect an unstructured, later to become structured, review and list of software and software libraries that can be used to: The mapping is done by analyzing both proprietary and free (open source) software, including SAAS (software as a service) and ones to be installed. Platform (Thanks Manlio Lo Giudice 07/01/2024) Free…

Hacking Biology (HB) is an applied research project that aim to bring a Do It Yourself (DIY) experimental protocol to address biological hallmark of aging. While we are neither developing a Trial Protocol, neither doing hot science, the protocol develop arounds scientific finding (being earlystage or established, having already had human testing or only on…